name

Human TNF-alpha / TNFA Protein/重组人 TNF-alpha /

Specification

20ug

Numbering

CZDB-006

price

enquiry

Chinese name

Human TNF-alpha / TNFA Protein/重组人 TNF-alpha /

Molecular Alias

TNF-alpha, TNF-a, Cachectin, DIF, TNFA, TNFSF2

molecular species

Mouse

expression tag

His，S

expression host

E. coli

concentration

> 95 % as determined by SDS-PAGE

buffer

Lyophilized from sterile PBS, pH 7.4

storage conditions

-70°C，repeated freezing and thawing should be avoided.

Basic description

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.