name

Rat HSPD1 / HSP60 Protein/重组大鼠HSPD1 / HSP60 蛋

Specification

20ug

Numbering

CZDB-010

price

enquiry

Chinese name

Rat HSPD1 / HSP60 Protein/重组大鼠HSPD1 / HSP60 蛋

Molecular Alias

HSPD1,HSP60

molecular species

Mouse

expression tag

His，S

expression host

E. coli

concentration

> 95 % as determined by SDS-PAGE

buffer

Lyophilized from sterile PBS, pH 7.4

storage conditions

-70°C，repeated freezing and thawing should be avoided.

Basic description

HSPD1, also known as HSP60, is a member of the chaperonin family. HSPD1 may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. It may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSPD1 gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4); also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. HSPD1 is cinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.