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|
name |
Mouse gp130 / IL6ST / CD130 Protein/重组小鼠 gp130 |
|
Specification |
20ug |
|
Numbering |
CZDB-001 |
|
price |
enquiry |
|
Chinese name |
重组小鼠 gp130 / IL6ST / CD130 protein |
|
Molecular Alias |
Ac1055, Gp130, Il-6rb |
|
molecular species |
Mouse |
|
expression tag |
His，S |
|
expression host |
E. coli |
|
concentration |
> 95 % as determined by SDS-PAGE |
|
buffer |
Lyophilized from sterile PBS, pH 7.4 |
|
storage conditions |
-70°C，repeated freezing and thawing should be avoided. |
|
Basic description |
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |