名称

Mouse TNF-alpha / TNFA Protein/重组小鼠TNF-alpha /

规格

20ug

编号

CZDB-005

价格

询价

中文名

Mouse TNF-alpha / TNFA Protein/重组小鼠TNF-alpha /

分子别称

TNF-alpha, TNF-a, Cachectin, DIF, TNFA, TNFSF2

分子种属

Mouse

表达标签

His，S

表达宿主

E. coli

浓度

> 95 % as determined by SDS-PAGE

缓冲液

Lyophilized from sterile PBS, pH 7.4

存储条件

-70°C，应避免反复冻融。

基本描述

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.